RAS (Recurrent Aphthous Stomatitis) is the majority common ulcerative illness affecting the oral mucosa. It occurs frequently in healthy individuals and has atypical clinical appearance in immunocompromised individuals. The etiology of RAS is still unidentified, but several local, general, immunologic, hereditary, allergic, nutritional, and microbial factors, as well as immunosuppressive drugs, have been anticipated as causative agents. Clinical management of RAS is based on severity of symptoms, frequency, size and number of lesions using topical and systemic therapies. The goals of therapy are to decrease pain and ulcer size, promote healing and decrease frequency of recurrence.
RAS has a quality prodromal burning feeling that lasts from 2 to 48 hours before an ulcer appears. It occurs in otherwise healthy individuals and is normally located on the buccal and labial mucosa and tongue. Participation of the heavily keratinized mucosa of the appetite and gingiva is less frequent.
Diseases which also grounds oral ulcers that may be mistaken for RAS include Behçet’s illness, cyclic neutropenia, recurring intraoral herpes infections, HIV-related oral ulcers or gastrointestinal illnesses such as Crohn’s illness and ulcerative colitis. It is incumbent upon the clinician organization oral illness to distinguish localized RAS from ulcers caused by an underlying systemic turmoil.
Several factors have been planned as possible causative agents for RAS. These comprise local factors, such as trauma in individuals who are hereditarily susceptible to RAS, microbial factors, nutritional factors, such as shortage of folate and B-complex vitamins, immunologic factors, psychosocial stress, and allergic reaction to dietary constituents1. Extensive research has alert predominantly on immunologic factors, but a ultimate etiology of RAS has yet to be obviously established.